Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells

Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells

Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony formation assay was used to evaluate the effect. Relative changes in expression of B...

Radiation Induced Bystander Effect

Introduction: Radiation effects observed in cells that are not irradiated are known as non-targeted effects.  Radiation induced bystander effect (RIBE) as a kind of non-targeted effect has been introduced in recent  years.  RIBE  occurs  in  unexposed  cells  which  are  related  to  adjacent  or  distant  irradiated  cells.  RIBE  contradict with "target theory" which necessitates radiation tr...

The Mechanisms of Radiation-Induced Bystander Effect

The radiation-induced bystander effect is the phenomenon which non-irradiated cells exhibit effects along with their different levels as a result of signals received from nearby irradiated cells. Responses of non-irradiated cells may include changes in process of translation, gene expression, cell proliferation, apoptosis and cells death. These changes are confirmed by results of some In-Vivo s...

Radiation-induced bystander effect and adaptive response in mammalian cells.

Two conflicting phenomena, bystander effect and adaptive response, are important in determining the biological responses at low doses of radiation and have the potential to impact the shape of the dose-response relationship. Using the Columbia University charged-particle microbeam and the highly sensitive AL cell mutagenic assay, we show here that non-irradiated cells acquire mutagenesis throug...

The Role of Target and Bystander Cells in Dose-Response Relationship of Radiation-Induced Bystander Effects in Two Cell Lines